You can build and generate applications on a remote machine as long as the network drive containing the application folder is mapped to your development machine. Note, however, Iron Speed Designer will attempt to run your application on your local Microsoft IIS web server. You may need to create a virtual directory and run your application manually if your application is on a remote machine.
You can also remote into another machine that has Designer, generate and build and app, and run it on the remote machine (assuming Microsoft IIS is installed, etc.)
System Requirement for Iron Speed Designer Software
Generated Application System Requirements
Application User System Requirements
.NET Framework 3.0 Compatibility for Iron Speed Designer
Activating and Deactivating Iron Speed Designer
Offline Activation of Iron Speed Designer
How to Check Your MDAC Version
Running Iron Speed Designer Remotely